Navigation Links
Intermediate filament


Intermediate filaments are one component of the cytoskeleton - important structural components of living cells. Their size is intermediate between that of microfilaments and microtubules. They are assembled from several different proteins. IFs crisscross the cytosol from the nuclear envelope to the cell membrane.

Contents

Types

The different kinds of IFs share some basic characteristics: they are from 9 to 11 nm. in diameter and are very stable; their main function being a structural one. Different types of IFs are distinguished by the protein each is made of.

Lamin IFs

These form a network, the nuclear lamina, that supports the nuclear envelope. There are lamin A, B, and C filaments. Lamin A and C form the lamin network and are attached to the nuclear membrane by lamin B.

(See also: nuclear envelope)

Keratin IFs

keratin intermediate filaments

These proteins are the most diverse among IFs. The many isoforms are divided in two groups: "soft" keratins (cytokeratins) in epithelial cells (image to right), and "hard" keratins (hair keratins) which make up hair, nails, horns and reptilian scales. Regardless of the group, keratin can be acidic or basic. Acidic and basic keratins can bind each other to form acidic-basic heterodimers, these heterodimers can then associate to make a keratin filament.

Type III IFs

Neurofilaments

These are found in nerve cells and are implicated in the radial growth of the axon.

  • α-Internexin
  • Neurofilament-L (NF-L)
  • Neurofilament-M (NF-M)
  • Neurofilament-H (NF-H)

Nestin

Intermediate filament type VI. It is found in neural stem cells.

Cell adhesion

At the plasma membrane, IFs are attached by adapter proteins forming desmosomes (cell-cell adhesion) and hemidesmosomes (cell-matrix adhesion).


'"/>


(Date:3/15/2016)... 15, 2016 Yissum Research Development Company ... company of the Hebrew University, announced today the formation ... technology of various human biological indicators. Neteera Technologies has ... from private investors. ... detection of electromagnetic emissions from sweat ducts, enables reliable ...
(Date:3/14/2016)... , Allemagne, March 14, 2016 ... ) - --> - Renvoi : image ... --> --> ... biométriques, fournit de nouveaux lecteurs d,empreintes digitales pour ... de DERMALOG sera utilisé pour produire des cartes ...
(Date:3/11/2016)... -- --> --> ... Market by Technology (Pattern Recognition), by Component (Hardware, Software, ... (On-Premises and Cloud), by Industry Vertical and by Region ... global market is expected to grow from USD 12.49 ... at a CAGR of 19.1%. , ...
Breaking Biology News(10 mins):
Other biology definition