Navigation Links
Tubulin


Tubulin is the protein which makes up microtubules. Microtubules are assembled from dimers of α- and β-tubulin. Each of these subunits has three domains. γ-tubulin is important in the nucleation and polar orientation of microtubule. Tubulin binds GTP and assembles onto the (+) ends of microtubules in the GTP-bound state. Once assembled into microtubules, it hydrolyzes GTP into GDP. The GDP-bound form of tubulin will disassemble from the tip of a microtubule, though it will not spontaneously fall out of the middle. This GTP cycle is essential for the dynamic instability of the microtubule.

Tubulin was long thought to be specific to eukaryotes. Recently, however, the prokaryotic cell division protein FtsZ was shown to be evolutionarily related to tubulin.

Delta and epsilon tubulin have been found to localize at centrioles and may play a role in forming the mitotic spindle during mitosis.

Pharmacology

Tubulins are targets for anticancer drugs like taxol. The anti-gout agent colchicine binds to tubulin and inhibits microtubule formation, arresting neutrophil motility and decreasing inflammation.



'"/>


(Date:12/17/2014)... 2014  Automation is fundamentally transforming the travel ... at international borders. Over the past decade, ePassports, ... veteran travelers to self process through border control ... at an increasing number of airports, seaports, and ... According to Maxine Most , Principal at ...
(Date:12/11/2014)... Dec. 10, 2014  That blood pressure plays a role ... Hypertension – the medical term for high blood pressure – ... and the inflatable cuff that,s used in measuring blood pressure ... there,s nothing new about hypertension, its triggers and its effects. ... the condition and the best ways to treat it. ...
(Date:12/10/2014)... WINSTON-SALEM, N.C. , Dec. 9, 2014  Wake Forest ... medical education building for its School of Medicine. Funding ... a larger capital campaign that will be publicly launched ... will be located in the former 60 series R.J. ... Forest Innovation Quarter. Construction will begin immediately with plans ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... of Medical Toxicology (ACMT) have signed an agreement to collaborate ... (JMT), the official journal of the ACMT, beginning in ... of Pennsylvania Press. The Journal of Medical ... the science and practice of medical toxicology. The quarterly ...
... is a matter of debate. A high-profile study a few ... their carbon from trees and leaves, evidence for a very ... new research from the University of Washington shows this is ... diet for fish and other aquatic life, according to research ...
... presents strong evidence that the "synergistic" effect of early-life ... causes more harm to developing lungs than one or ... scientists at the University of Cincinnati (UC) College of ... levels of traffic-related particles and indoor endotoxin during early ...
Cached Biology News:Springer and the American College of Medical Toxicology to work together 2Fish food fight: Fish don't eat trees after all, says new study 2Fish food fight: Fish don't eat trees after all, says new study 3Exposure to both traffic, indoor pollutants puts some kids at higher risk for asthma later 2
Other biology definitionOther Tags