Navigation Links
Tubulin


Tubulin is the protein which makes up microtubules. Microtubules are assembled from dimers of α- and β-tubulin. Each of these subunits has three domains. γ-tubulin is important in the nucleation and polar orientation of microtubule. Tubulin binds GTP and assembles onto the (+) ends of microtubules in the GTP-bound state. Once assembled into microtubules, it hydrolyzes GTP into GDP. The GDP-bound form of tubulin will disassemble from the tip of a microtubule, though it will not spontaneously fall out of the middle. This GTP cycle is essential for the dynamic instability of the microtubule.

Tubulin was long thought to be specific to eukaryotes. Recently, however, the prokaryotic cell division protein FtsZ was shown to be evolutionarily related to tubulin.

Delta and epsilon tubulin have been found to localize at centrioles and may play a role in forming the mitotic spindle during mitosis.

Pharmacology

Tubulins are targets for anticancer drugs like taxol. The anti-gout agent colchicine binds to tubulin and inhibits microtubule formation, arresting neutrophil motility and decreasing inflammation.



'"/>


(Date:8/3/2015)... Aug. 3, 2015 Synaptics, Inc. (Nasdaq: ... today announced that members of the executive management team ... Crest Global Technology Leadership Forum on Tuesday, August 11, ... be held at the Sonnenalp Resort in ... may include forward-looking information. An audio webcast of the ...
(Date:7/31/2015)... 31 juillet 2015 La 10e Conférence ... sera organisée par le BGI du 22 au ... en Chine. La conférence célèbre ... en 2006, l,ICG est devenue l,une des réunions ... des « omiques » et c,est aussi la plus dynamique, ...
(Date:7/31/2015)... 31, 2015 The 10 th International Conference ... BGI from October 22-25, 2015, in Shenzhen , ... is celebrating its 10 th anniversary this year. Since its ... most influential annual meetings in the ,omics, fields, and is ... ICG-10 focuses on recent breakthroughs and advances ...
Breaking Biology News(10 mins):La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 2La 10e International Conference on Genomics (ICG-10) doit s'ouvrir en octobre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... to use circle hooks in some fishing tournaments because ... billfish, such as marlin. However, research from North Carolina ... adversely impact charter and recreational fishing, since they make ... to know whether circle hooks are effective as conventional ...
... cancers are increasingly successful with cure rates approaching 80%, but ... the cancer treatments they received as boys can leave them ... Brinster of the University of Pennsylvania School of Veterinary Medicine ... technique that could restore their fertility. Brinster ...
... -- Life deep in the seabed proceeds very slowly. ... play an important role in the global storage of organic ... scientists from Aarhus University (Denmark) and the University of Rhode ... life deep down in the seabed. Their findings ...
Cached Biology News:Study finds circle hooks lower catch rate for offshore anglers 2Penn research points to new way of preserving fertility for boys undergoing cancer treatment 2Penn research points to new way of preserving fertility for boys undergoing cancer treatment 3Oceanographers develop method for measuring the pace of life in deep sediments 2
Other biology definitionOther Tags