Navigation Links
Spliceosome


A spliceosome is a complex of RNA and many protein subunits, that remove the non-coding introns from unprocessed mRNA. The mRNA of prokaryotes is simpler, and they do not have introns, so only eukaryotes have spliceosomes. The RNAs that spliceosomes consist of are named U1, U2, U4, U5, and U6, and participate in several RNA-RNA and RNA-protein interactions. The RNA part is rich in uridine (the U nucleotides). There are specific 5' and 3' sites on the pre-mRNA that the spliceosome recognises. The area between these locations is removed, and the two exons are spliced together.

Alternative splicing

Alternative splicing (the re-combination of different introns) is a major source of genetic diversity in eukaryotes. For example alternative splicing is what makes our immune systems so diverse (much more diverse, for example, than a simple recombination of our parents immune systems.)

Splice variants have been used to account for the relatively small number of genes in the human genome. For years the estimate was 100,000 genes, but now, thanks to the Human Genome Project we know the figure is closer to 30,000 genes. However, almost every human gene is thought to have at least two isoforms.

Spliceome

The term spliceome has been recently coined to describe the complete set of all possible alternative splices in an organism, in analogy to the genome or proteome. It is defined as a concept for the convenience of computer scientists working together with molecular biologists and bioinformaticians.


External links and references


'"/>


(Date:10/15/2014)... German Gauß-Allianz has admitted Johannes Gutenberg University Mainz ... Rhineland-Palatinate science hub continues to maintain a significant ... , "The acceptance of Johannes Gutenberg University ... is a milestone in the national and international ... The state of Rhineland-Palatinate can be proud that ...
(Date:10/15/2014)... SHELTON, Conn. , Oct. 15, 2014 NXT-ID, Inc. ... a biometric authentication company focused on the growing mobile commerce market ... NASDAQ MarketSite in Times Square on Monday October 13 th . ... with CTO David Tunnel and angel investor Mr. ... Gino Pereira , CEO of NXT-ID thanked his investors and employees ...
(Date:10/14/2014)... discriminating thieves, prostate cancer tumors scavenge and hoard copper ... such avarice may be a fatal weakness. , ... kill prostate cancer cells by delivering a trove of ... diseased cells brimming with the mineral, leaving non-cancer cells ... already commercially available for other uses, could soon be ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3Prostate cancer's penchant for copper may be a fatal flaw 2
... exposure, serving size and parental behavior are the key drivers ... discussion at the 2013 Institute of Food Technologists (IFT) Annual ... standing-room only crowd of more than 200 conference attendees heard ... what their eating behaviors are and how the industry and ...
... approved to treat multiple sclerosis may also hold promise for ... that often leads to heart failure, researchers at the University ... findings are published in the July 16 issue of ... thickening of the heart muscle that shrinks the interior ...
... have taken part in an international study which has revealed ... in one of the most hostile environments on earth. ... Tibetan plateau, the largest high-altitude land mass in the world. ... genome which reveal how it copes with the extreme living ...
Cached Biology News:Taste rules for kids and healthy food choices 2MS drug shows promise for preventing heart failure 2Genetic secrets of the world's toughest little bird 2Genetic secrets of the world's toughest little bird 3
Other biology definitionOther Tags