Navigation Links
Microbiology


Microbiology (in Greek micron = small and biologia = studying life) is the study of microorganisms, including viruses, prokaryotes and simple eukaryotes. Today, most of the work in microbiology is done using methods from biochemistry and genetics. It is also related to pathology, immunology, and epidemiology as many microorganisms are pathogens.

Microbiologists have made many fundamental contributions to biology and medicine, especially in the fields of biochemistry, genetics, and cell biology. Microbes have many traits that make them ideal model organisms:

  • They are small, therefore they do not consume many resources
  • Some have very short generation times (the time needed for division of a bacterial cell in two in optimal conditions; ~30 minutes for E. coli, but 12 to 24 hours for Mycobacterium tuberculosis)
  • Cells can easily survive in isolation from other cells
  • Unicellular eukaryotes reproduce by mitotic division and prokaryotes by binary fission. This allows for the propagation of genetically identical (clonal) populations.
  • They may be frozen for long periods of time. Even if 90% of the cells are killed by the freezing process, there are millions of cells in a milliliter of liquid culture.

These traits allowed Joshua and Esther Lederberg to devise an elegant experiment in 1951 demonstrating that adaptive mutations arise from preadaptation rather than directed mutation. For this purpose, they invented replica plating, which allowed them to transfer numerous bacterial colonies from their specific locations on one agar-filled petri dish to analogous locations on several other petri dishes. After replicating a plate of E. coli, they exposed each of the new plates to a bacteriophage (also called phage). They observed that phage-resistant colonies were present at analogous locations on each of the plates, allowing them to conclude that the phage resistance trait had existed in the original colony, which had never been exposed to phage, instead of arising after the bacteria had been exposed to the virus.

The extensive characterization of microbes has allowed them to be used in industry and as experimental tools in different branches of biology:

  • Bacteria and simple eukaryotes contain small circular DNAs, called plasmids. Plasmids can be genetically modified in vitro then inserted into bacteria that are grown in a culture to produce large amounts of protein using genes encoded on a plasmid. The proteins produced vary widely, some of them are for example antibiotics.
  • Many microbes exploit energy by the process of anaerobic fermentation, in which different simple organic molecules are produced. This gave rise to the science of industrial fermentation . In this way it is possible to produce different antibiotics, beer, vinegar and other substances.
  • Bacterial genes have been inserted into other organisms as reporter genes.
  • The yeast two-hybrid system combines bacterial genes with genes from the organism being studied and inserts them into yeast cells to study protein-protein interactions within a cellular environment.

See also


Return to Biology, Category:Biology

External links

[[uk:Мікробіологія


'"/>


(Date:11/11/2014)... Nov. 11, 2014  Forensicon, Inc., a ... pleased to announce the promotion of Yaniv Schiff ... Digital Forensics. In Schiff,s new role as Director, he ... of digital forensics examiners and provide leadership within the ... - http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined ...
(Date:11/7/2014)... Debra Auguste, associate professor, biomedical engineering, in the ... of New York, have identified a molecule that ... the most aggressive forms of breast cancer. , ... mortality rate owing to aggressive proliferation and metastasis ... Professor Auguste,s team, discovered the overexpression of intercellular ...
(Date:11/7/2014)... CORAL SPRINGS, Florida , November 6, 2014 ... improved secure authentication for better mobile security revolutionizing online transactions. ... NXTD ), Alibaba Holdings Ltd. (NYSE: BABA ), ... MSFT ), eBay Inc. (NASDAQ: EBAY ... (NASDAQ: NXTD and NXTDW), a biometric authentication ...
Breaking Biology News(10 mins):Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... A new study from the Center for Interdisciplinary ... an additional link between Light At Night (LAN) and ... carried out at the University of Haifa that also ... to ,environmental light pollution, which the study has shown ...
... is fascinating to watch the orderly and seemingly choreographed ... or insects. However, the formation and the manifold motion ... the understanding of complex systems. A team of physicists ... developed a versatile biophysical model system that opens the ...
... Purdue University researchers have developed a new type of ... "microneedles" to deliver a wider range of medications than ... patches are limited to delivering drugs that, like nicotine, ... absorbed through the skin, said Babak Ziaie, a professor ...
Cached Biology News:Connection between light at night (LAN) and cancer revealed in additional study 2A model system for group behavior of nanomachines 2A model system for group behavior of nanomachines 3New pump created for microneedle drug-delivery patch 2
Other biology definitionOther Tags