Navigation Links
Har Gobind Khorana


Har Gobind Khorana (born January 9, 1922) is a molecular biologist.

Khorana was born in Raipur (at that time India, now Pakistan). In 1945, he began studies at the University of Liverpool. After earning a Ph. D., he spend a postdoc year in Zrich (1948-49). He then returned to England and worked at Cambridge until 1952. He married Esther Elizabeth Sibler the same year. After that, he worked at universities in Vancouver and Wisconsin.

Khorana was awarded the 1968 Nobel Prize in Medicine (together with Robert W. Holley and Marshall W. Nirenberg) for describing the genetic code and how it operates in protein synthesis.

Khorana's synthetic RNA approach

RNAs with two repeating units (UCUCUCU → UCU CUC UCU) produced two alternating amino acids. This combined with the Nirenberg and Leder experiment showed that UCU codes for Ser and CUC for Leu.

RNAs with three repeating units (UACUACUA → UAC UAC UAC, or ACU ACU ACU, or CUA, CUA, CUA) produced three different strings of amino acids.

RNAs with four repeating units including UAG, UAA, or UGA, produced only dipiptides and tripeptides thus revealing that UAG, UAA and UGA are stop codons.

With this Dr.khorana and his team had established that the mother of all codes, the biological language common to all living organisms, is spelled out in three-letter words:each set of three nucleotides codes for a specific amino acid, in their Nobel lecture delivered on December 12,1968. Dr.Khorana was also the first to synthesize oligonucleotides , that is, strings of nucleotides. These custom designed pieces of artificial genes are widely used in biology labs for sequencing, cloning and engineering new plants and animals.Dr.khorana's invention of oligonucleotides has become indispensable tools in biotechnology. This invention of DrKhorana has become mechanized and commercialize that anyone now can order the synthetic genes just he needs to fax the genetic sequence.


'"/>


(Date:7/11/2014)... started near the City of Entiat on Tuesday, July ... fire quickly grew to over 1,000 acres by evening. ... is under investigation by the Washington Department of Natural ... local resources in developing fire control strategies and tactics. ... State Department of Natural Resources, (WA DNR), Bureau of ...
(Date:7/11/2014)... scientists have set a "mouse TRAP" to capture the ... recent study published in the Journal of Clinical ... technique called TRAP to extract cellular and genetic information ... scientists at the Rockefeller Institute for Medical Research in ... protein-making machinery, or ribosomes, of the cell type of ...
(Date:7/11/2014)... group members to reduce aggression and gain access to ... grooming activities shows a certain pattern across the day. ... Biology Letters . , Grooming between individuals in ... motives. To be groomed has hygienic benefits and is ... can provide access to infants, mating opportunities and high ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2
... almost 30 years, researchers have sought to identify a ... during photosynthesis. A team at Ludwig-Maximilians-Universitt (LMU) in Munich ... to be an old acquaintance. Photosynthesis sustains ... molecular oxygen that higher organisms depend on. The process ...
... Marine resource managers often gauge the health of species ... relationships in the Bering Sea found that it isn,t the ... how densely they are aggregated. It,s more than searching ... balance how much energy they expend in searching for food ...
... make animals, well, brainier, but that boost in brain size ... evidence reported on January 3rd in Current Biology , ... for large and small brain sizes. The findings lend ... ability do go together, a topic that has been a ...
Cached Biology News:Photosynthesis: The last link in the chain 2Bering Sea study finds prey density more important to predators than biomass 2Bering Sea study finds prey density more important to predators than biomass 3Big brains are pricey, guppy study shows 2
Other biology definitionOther Tags